TORPHADINE (BUTORPHANOL TARTRATE INJ) 10MG/ML 50ML VL C4 VINV-C0IV-0030

TORPHADINE (Butorphanol Tartrate Injection) 10mg/mL, supplied in a 50mL vial, is a Schedule IV controlled substance manufactured by Dechra and distributed by Amatheon Animal Health. This synthetic opioid analgesic is widely used in veterinary medicine for the management of moderate to severe pain in dogs, cats, and horses. As an agonist-antagonist, butorphanol activates kappa opioid receptors while blocking mu receptors, delivering effective analgesia with a lower risk of respiratory depression compared to full mu-opioid agonists like morphine. Administered by injection, this medication offers rapid onset and a duration of action lasting several hours. It is particularly effective for perioperative anesthesia support, acute pain management, and in some cases, for controlling cough due to its antitussive properties. Additionally, butorphanol exhibits antiemetic activity, helping to reduce nausea in certain clinical scenarios, making it a versatile option in veterinary care. Though generally well tolerated, possible side effects include sedation, nausea, mild gastrointestinal changes, or respiratory depression—especially at higher doses. In cases of overdose, symptoms may include CNS depression, respiratory difficulty, or seizures, which require prompt veterinary intervention. Naloxone may be used to reverse the effects in emergencies. Use with caution in animals with impaired kidney or liver function, and avoid combining with other central nervous system depressants unless under close supervision. Veterinarians should provide detailed guidance on dosing, administration, and monitoring to ensure safe and effective use of this analgesic agent in animal patients.